Evaluation of ideological and political teaching quality of physiology course for rehabilitation

The development of the information industry is a cross-era impact for any industry, especially under the influence of the database, and the systematic analysis of the data in the industry can improve the accuracy of the output vector and data analysis. With the increase of data volume, for the difficulty of data processing increased significantly, the number of college students growing rapidly in recent years, to the accurate analysis of teachers and students need to take information technology, improve the accuracy of the operation, in the analysis of students and teachers through the system processing education data, the results can be applied to the education management. Based on the above content, on the basis of the dragonfly algorithm, through the improvement of the algorithm, the quality of rehabilitation physiology ideological teaching evaluation, first constructed the course ideological teaching quality evaluation system, then on the basis of determining the evaluation index, the teaching quality evaluation score, in order to through the study of rehabilitation physiology ideological teaching quality to provide reference (AU)

Glycyrrhizin affects malignant biological behaviors of non-small cell lung cancer HCC827 andA549 cells via regulating miR-142/ZEB1 axis / 中国肿瘤生物治疗杂志

@#Objective: To explore the effect of glycyrrhizin (GA) on the proliferation, invasion and migration of non-small cell lung cancer HCC827 andA549 cells via regulating miR-142/ZEB1 (Zinc finger E-box-binding homeobox 1) axis. Methods:After being cultured and transfected, HCC827 andA549 cells were divided into 4 groups: NC group (untransfected+3 mmol/L GA), miR-142 inhibitor group (miR-142 knockdown+3 mmol/L GA), pcDNA3.1-ZEB1 group (ZEB1 over-expression+3 mmol/L GA) and pcDNA3.1-ZEB1+ miR-142 mimic group (ZEB1 over-expression+miR-142+3 mmol/L GA). qPCR was used to detect the expression level of miR-142 in HCC827 andA549 cells treated with different concentrations of GA. MTT and Transwell assays were used to examine the proliferation, invasion and migration of HCC827 and A549 cells. WB was used to detect the expression level of ZEB1 protein in HCC827 and A549 cells. Dual-luciferase reporter gene assay was used to explore the relationship between miR-142 and ZEB1. Results: GA significantly inhibited the proliferation, invasion and migration of HCC827 and A549 cells, and up-regulated the expression level of miR-142 ( P < 0.05 or P <0.01). Dual-luciferase reporter gene assay showed that miR-142 could targetedly combine with 3'-UTR of ZEB1 and downregulate the expression of ZEB1 ( P <0.05 or P <0.01). Further experiment validated that GAinhibited ZEB1 expression via up-regulating miR-142, thus suppressed proliferation, invasion and migration of HCC827 and A549 cells ( P <0.05 or P <0.01). Conclusion: GA inhibits the proliferation, invasion and migration of NSCLC HCC827 and A549 cells, the mechanism of which is that GA inhibits the malignant biological behavior of NSCLC HCC827 andA549 cells via up-regulating the inhibition effect of miR-142 on ZEB1.